Granny arranged to return in French city (6)
I believe the answer is:
nantes
'french city' is the definition.
(Nantes is a city in France)
'granny arranged to return' is the wordplay.
'granny' becomes 'nan'.
'arranged' becomes 'set' (similar in meaning).
'to return' says the letters should be written in reverse.
'set' written backwards gives 'tes'.
'nan'+'tes'='NANTES'
'in' is the link.
(Other definitions for nantes that I've seen before include "French FC" , "port abroad" , "French Atlantic port" , "in Pays de la Loire?" , "A major French port" .)