Great hotel plastered completely (10)
I believe the answer is:
altogether
'completely' is the definition.
(I know that completely can be written as altogether)
'great hotel plastered' is the wordplay.
'plastered' indicates anagramming the letters (plastered can informally mean drunk).
'great'+'hotel'='greathotel'
'greathotel' with letters rearranged gives 'ALTOGETHER'.
(Other definitions for altogether that I've seen before include "totally" , "nude in this" , "Entirely" , "Wholly" , "special to get Hermes trousers" .)