Great sorrow (3)
I believe the answer is:
woe
'great sorrow' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for woe that I've seen before include "Misery - tribulation" , "Archaic sorrow or grief" , "Misery, wretchedness" , "Alas!" , "Grief, misery" .)