Great sorrow or distress (3)
I believe the answer is:
woe
I believe this is a double definition.
'great sorrow' is the first definition.
(I've seen this before)
'distress' is the second definition.
(I've seen this in another clue)
(Other definitions for woe that I've seen before include "Tale content?" , "Trouble" , "Difficulty" , "'Wednesday's child is full of ...'" , "Misfortune" .)