Greatly hampered with husband’s unwillingness to move (8)
I believe the answer is:
lethargy
'unwillingness to move' is the definition.
'greatly hampered with husband's' is the wordplay.
'hampered with' indicates anagramming the letters ('hampered' can mean entangled).
'husband' becomes 'h'.
'greatly' anagrammed with 'h' gives 'LETHARGY'.
(Other definitions for lethargy that I've seen before include "state of apathy" , "Lassitude, sluggishness" , "Lassitude, languor" , "Inertia" , "Lack of vitality or energy" .)