Greatness can emerge from Harpenden (or MIT/Yale) (8)
I believe the answer is:
enormity
'greatness' is the definition.
(thesaurus)
'can emerge from harpenden or mityale' is the wordplay.
'can emerge from' indicates a hidden word (the answer comes out of the clue).
'ENORMITY' can be found hidden inside 'harpenden or mityale'.
(Other definitions for enormity that I've seen before include "Atrociousness" , "major crime" , "Shocking act" , "Grave crime or sin" , "Evil" .)