Greed hit a large town (8)
I believe the answer is:
rapacity
'greed' is the definition.
('rapacity' can be a synonym of 'greed')
'hit a large town' is the wordplay.
'hit' becomes 'rap' (I've seen this in other clues).
'large town' becomes 'city' (I've seen this before).
'rap'+'a'+'city'='RAPACITY'
(Other definitions for rapacity that I've seen before include "Voraciousness" , "excessive greed" , "Greed, the plundering of others" , "Greedy and grasping quality of plundering and exploiting others" , "Predatory greed and extortion" .)