Guard your marbles? (4)
I believe the answer is:
mind
'marbles?' is the definition.
(thesaurus)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for mind that I've seen before include "Consciousness" , "Intelligence" , "Intellect; object to" , "'Out of sight, out of ....'" , "Look after" .)