Guide worked with hands (6)
I believe the answer is:
manual
'guide' is the definition.
(I've seen this before)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for manual that I've seen before include "Instruction book prepared by hand?" , "Relating to the hands" , "Working with the hands" , "Involving human effort" , "Book of instructions" .)