Guided around snake, ran (8)
I believe the answer is:
laddered
'ran' is the definition.
('ladder' can be a synonym of 'run')
'guided around snake' is the wordplay.
'guided' becomes 'led' ('lead' can be a synonym of 'guide').
'around' is an insertion indicator.
'snake' becomes 'adder' (adder is a kind of snake).
'led' going around 'adder' is 'LADDERED'.
(Other definitions for laddered that I've seen before include "ran" , "Unravelled, stocking for instance" , "Descriptive of a stocking with a run" , "(Of tights or stockings) having a run" , "Guided around snake" .)