Guzzler emptied wine bottle (4)
I believe the answer is:
grit
'bottle' is the definition.
(I've seen this before)
'guzzler emptied wine' is the wordplay.
'emptied' suggests removing the centre.
'wine' becomes 'it' (I've seen this in other clues).
'guzzler' with its centre taken out is 'gr'.
'gr'+'it'='GRIT'
(Other definitions for grit that I've seen before include "Stone particles; pluck" , "Hard particles for firmness of character" , "Small particles of stone or sand" , "Indomitability" , "Fine stones or sand" .)