Had an effect before other changes up to now (8)
I believe the answer is:
hitherto
'up to now' is the definition.
(I've seen this in another clue)
'had an effect before other changes' is the wordplay.
'had an effect before' becomes 'hit' (I am not sure about this - if you are sure you should believe this answer much more).
'changes' indicates an anagram.
'other' is an anagram of 'herto'.
'hit'+'herto'='HITHERTO'
Can you help me to learn more?
(Other definitions for hitherto that I've seen before include "So far" , "Up till now" , "Heretofore (8" , "Up to this point" , "Up to this time" .)