Half of the population lose the head because it could portend disaster (4)
I believe the answer is:
omen
'portend disaster' is the definition.
'omen' can be an answer for 'portend' (synonyms). I am unsure of the 'disaster' bit.
I can't explain the remainder of the clue.
Can you help me to learn more?
(Other definitions for omen that I've seen before include "Warning token" , "Prognostication" , "Harbinger, prophetic sign" , "Portent of things to come" , "Augur" .)