Hand opening tin for produce (5)
I believe the answer is:
spawn
'for produce' is the definition.
(to spawn is to produce offspring)
'hand opening tin' is the wordplay.
'hand' becomes 'paw' (synonyms).
'opening' is an insertion indicator (some letters open a gap in others).
'tin' becomes 'Sn' (Sn is the chemical symbol for tin).
'paw' inserted within 'sn' is 'SPAWN'.
(Other definitions for spawn that I've seen before include "Product" , "Yield" , "offspring" , "generator" , "Give rise to; fish egg" .)