Handbook describes part of organ? (6)
I believe the answer is:
manual
'handbook' is the definition.
(manual is a kind of handbook)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for manual that I've seen before include "Done by hand, or a handbook" , "Handy" , "Involving human effort" , "Physical hard work" , "Work-book" .)