Handle business exercise (4)
I believe the answer is:
cope
'handle' is the definition.
(I've seen this in another clue)
'business exercise' is the wordplay.
'business' becomes 'co' (short for company).
'exercise' becomes 'pe' (Physical Education).
'co'+'pe'='COPE'
(Other definitions for cope that I've seen before include "Firmly based (in)" , "Priest's ceremonial cloak" , "Priest's cloak; deal (with)" , "Manage, make do" , "loser of Prestonpans" .)