Handle first fruit picker held in both hands (5)
I believe the answer is:
lever
'handle' is the definition.
(I've seen this before)
'first fruit picker held in both hands' is the wordplay.
'first fruit picker' becomes 'Eve' (Eve ate the forbidden fruit).
'held in' is an insertion indicator.
'both hands' becomes 'lr' (abbreviations for left and right).
'eve' put inside 'lr' is 'LEVER'.
(Other definitions for lever that I've seen before include "Crowbar" , "Jemmy" , "Rigid bar pivoting about a fulcrum" , "Means of exerting force" , "Bar operating machinery" .)