Hard for regulars to make trouble (3)
I believe the answer is:
ado
'trouble' is the definition.
(both can mean bother or commotion)
'hard for regulars' is the wordplay.
'regulars' indicates alternate letters (letters selected at regular intervals).
'hard'+'for'='hardfor'
The alternating letters of 'hardfor' are 'ADO'.
'to make' acts as a link.
(Other definitions for ado that I've seen before include "stir" , "Goings-on" , "Fuss, bother" , "Flurry" , "Flap" .)