Harm - defeat (4)
I believe the answer is:
loss
This clue is a double definition.
'harm' is the first definition.
(thesaurus)
'defeat' is the second definition.
(I've seen this in another clue)
(Other definitions for loss that I've seen before include "Big band leader" , "Destruction" , "Deficit" , "disappearance" , "Failure to profit or succeed" .)