Harmless guy's first seen in African country (6)
I believe the answer is:
benign
'harmless' is the definition.
(associated in meaning)
'guy's first seen in african country' is the wordplay.
'guy's first' becomes 'g' (1st letter of 'guy').
'seen in' is an insertion indicator.
'african country' becomes 'benin' (country in Africa).
'g' placed into 'benin' is 'BENIGN'.
(Other definitions for benign that I've seen before include "Mild and gentle, not malignant" , "Kindly, pleasant" , "Salubrious" , "Meaning no harm" , "Genial, kindly" .)