Harmony in a musical instrument (10)
I believe the answer is:
concertina
'musical instrument' is the definition.
(concertina is a kind of musical instrument)
'harmony in a' is the wordplay.
'harmony' becomes 'concert' (I've seen this in another clue).
'concert'+'in'+'a'='CONCERTINA'
(Other definitions for concertina that I've seen before include "Squeeze box" , "Squeeze-box" , "Collapse" , "Instrument played like an accordion" , "gig belonging to American" .)