Harrison used to carry the burden (4)
I believe the answer is:
onus
'the burden' is the definition.
(synonyms)
'harrison used to carry' is the wordplay.
'to carry' indicates the answer is hidden within the clue (I've seen 'carrying' mean this).
'ONUS' is hidden in the letters of 'harrison used'.
(Other definitions for onus that I've seen before include "'Burden, load (4)'" , "Obligation - charge" , "Weight of responsibility" , "Burden, duty" , "Duty or responsibility" .)