Has been worried, you know, and agitated (6)
I believe the answer is:
shaken
'agitated' is the definition.
('shake' can be a synonym of 'agitate')
'has been worried you know' is the wordplay.
I cannot really understand how this works, but
an anagram of 'has' is 'sha' which is present in the answer.
'know' could be 'ken' (I've seen this in another clue) and 'ken' is found in the answer.
No letters remain.
This may be the basis of the clue (or it may be nonsense).
'and' acts as a link.
Can you help me to learn more?
(Other definitions for shaken that I've seen before include "Upset - rattled" , "Having been shocked or disturbed" , "Distressed" , "jarred" , "James Bond liked his martinis this way, not stirred" .)