Has ref blown up again? (6)
I believe the answer is:
afresh
'again?' is the definition.
(synonyms)
'has ref blown up' is the wordplay.
'blown up' indicates an anagram.
'has'+'ref'='hasref'
'hasref' is an anagram of 'AFRESH'.
(Other definitions for afresh that I've seen before include "Anew, from the beginning" , "Newly" , "Academy award" , "In a new way" , "In a different way" .)