Hate Barbara regularly coming round house (5)
I believe the answer is:
abhor
'hate' is the definition.
(abhorring is a kind of hating)
'barbara regularly coming round house' is the wordplay.
'regularly' means one should take alternating letters (regularly take one letter, leave next etc.).
'coming round' is an insertion indicator.
'house' becomes 'ho' (abbreviation for house).
The alternating letters of 'barbara' are 'abr'.
'abr' enclosing 'ho' is 'ABHOR'.
(Other definitions for abhor that I've seen before include "Loathe, find repugnant" , "Regard with disgust and hatred" , "Find horrible" , "Despise" , "Sea between Africa and Australia" .)