Have left speaking; I don’t react (5)
I believe the answer is:
argon
'i don't react' is the definition.
(noble gases like argon aren't very reactive)
I don't understand how the remainder of the clue works.
(Other definitions for argon that I've seen before include "Chemical element" , "Gas, 1% of atmosphere" , "Organ (anag.)" , "Inert gas used in light bulbs" , "Inert gas in atmosphere" .)