Have the audacity to reject initial synopsis (6)
I believe the answer is:
resume
'synopsis' is the definition.
(thesaurus)
I don't understand the remainder of the clue.
Can you help me to learn more?
(Other definitions for resume that I've seen before include "Short descriptive summary" , "account, in brief" , "Continue after interruption" , "Begin activity again" , "Pick up again" .)