Having major trouble with a wart! (2,3)
I believe the answer is:
at war
'having major' is the definition.
I can't judge whether this defines the answer.
'trouble with a wart' is the wordplay.
'trouble' indicates anagramming the letters.
'with' means one lot of letters go next to another.
'a' put next to 'wart' is 'awart'.
'awart' is an anagram of 'AT WAR'.
Can you help me to learn more?
(Another definition for at war that I've seen is " In conflict".)
I've seen this clue in the Evening Standard.
Want a hint initially instead of a full solution?
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