He and Carol suffering disease (7)
I believe the answer is:
cholera
'disease' is the definition.
(cholera is a kind of disease)
'he and carol suffering' is the wordplay.
'and' is a charade indicator (letters next to each other) (I've seen this in other clues).
'suffering' indicates anagramming the letters.
'he' after 'carol' is 'carolhe'.
'carolhe' is an anagram of 'CHOLERA'.
(Other definitions for cholera that I've seen before include "bacterial disease" , "Infectious disease causing severe bowel upset" , "Infectious and often fatal Asiatic disease" , "Infectious and often fatal intestinal disease (7" , "serious illness" .)