He can't lose! (6)
I believe the answer is:
victor
'he can't lose' is the definition.
The answer is a person as well as being a singular noun. This is suggested by the definition.
'he can't' is the wordplay.
'he' becomes 'Vic' (short for Victor).
'can't' becomes 'tor' (I can't justify this - if you can you should believe this answer much more).
'vic'+'tor'='VICTOR'
Can you help me to learn more?
(Other definitions for victor that I've seen before include "Competitor who's first" , "Meat; complain" , "The one who wins the battle" , "whiskey after this" , "''To the . . . . . . the spoils'' (6)" .)