He comes from Constantinople - or Istanbul if you prefer (4)
I believe the answer is:
stan
'he' is the definition.
'constantinople or istanbul if you prefer' is the wordplay.
'STAN' is hidden in amongst the letters.
However, I am not sure how the hidden word is indicated.
'comes from' acts as a link.
Can you help me to learn more?
(Other definitions for stan that I've seen before include "One of the comic duo" , "Laurel and Hardy, . . . . and Ollie" , "Laurel perhaps" , "- Laurel, Hardy's partner" , "Eminem hit; man's name" .)