He fell out of sympathy with his partner (4)
I believe the answer is:
adam
This clue might be a double definition.
'he' is the first definition.
'fell out of sympathy with his partner' is the second definition.
The answer is a person as well as being a singular noun. This is suggested by the definition.
Can you help me to learn more?
(Other definitions for adam that I've seen before include "- - Bede, novel" , "the first orphan?" , "First Christian ancestor" , "First guy" , "Eden man" .)