He makes us cry (5)
I believe the answer is:
cyrus
'he' is the definition.
'makes us cry' is the wordplay.
'makes' indicates anagramming the letters.
'us'+'cry'='uscry'
'uscry' anagrammed gives 'CYRUS'.
(Other definitions for cyrus that I've seen before include "Early Persian ruler" , "Great Persian king" , "American chap?" , "Ancient king of Persia" .)