He presumably gives comprehensive orders (7)
I believe the answer is:
general
'he presumably gives comprehensive orders' is the definition.
The answer is a person as well as being a singular noun. This is suggested by the definition.
'he' is the wordplay.
I cannot quite understand how this works, but
'he' could be 'gene' and 'gene' is present in the answer.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for general that I've seen before include "Military commander" , "High ranking officer" , "Concerning all or most" , "Not specialised, rank" , "blanket" .)