He searched all over the place -- reaction with nothing found? (4,6)
I believe the answer is:
hard cheese
'he searched all over the place reaction with nothing found?' is the definition.
The definition suggests a singular noun which matches the answer.
'he searched all over the place' is the wordplay.
'all over the place' indicates an anagram.
'he'+'searched'='hesearched'
'hesearched' anagrammed gives 'HARD CHEESE'.
Can you help me to learn more?
(Other definitions for hard cheese that I've seen before include "Expression of sympathy" , "Pecorino" , "Leicester" , "Bad luck! (Grate it!)" , "Che sfortuna!" .)