Head inserted, shifted down (12)
I believe the answer is:
disheartened
'down' is the definition.
(thesaurus)
'head inserted shifted' is the wordplay.
'shifted' is an anagram indicator.
'head'+'inserted'='headinserted'
'headinserted' with letters rearranged gives 'DISHEARTENED'.
(Other definitions for disheartened that I've seen before include "Discouraged" , "Despondent" , "Having lost determination or confidence" , "Upset; downcast" , "Crestfallen" .)