Healthy wife cooks sole in residence (9)
I believe the answer is:
wholesome
'healthy' is the definition.
(similar in meaning)
'wife cooks sole in residence' is the wordplay.
'wife' becomes 'w' (abbreviation).
'cooks' is an anagram indicator.
'in' is an insertion indicator.
'residence' becomes 'home' (home is a kind of residence).
'sole' with letters rearranged gives 'leso'.
'leso' placed within 'home' is 'holesome'.
'w'+'holesome'='WHOLESOME'
(Other definitions for wholesome that I've seen before include "Beneficial" , "Respectable" , "Healthy in body, taste or morals" , "Previously propitious" , "Good for you!" .)