Heartlessly heckled, take notice (4)
I believe the answer is:
heed
'take notice' is the definition.
(I've seen this before)
'heartlessly heckled' is the wordplay.
'heartlessly' suggests removing the centre.
'heckled' with its centre taken out is 'HEED'.
(Other definitions for heed that I've seen before include "Be mindful of" , "Consider" , "Listen to carefully" , "Care, attention (paid)" , "Obey" .)