Henry, going off with boss to make big discovery in physics (5,5)
I believe the answer is:
higgs boson
'make big discovery in physics' is the definition.
I know nothing about this answer so I cannot judge whether this works.
'henry going off with boss' is the wordplay.
'henry' becomes 'H' (symbol for the unit of electrical inductance).
'off with' indicates an anagram.
'going' anagrammed with 'boss' makes 'iggsboson'.
'h'+'iggsboson'='HIGGS BOSON'
'to' is the link.
Can you help me to learn more?
(Another definition for higgs boson that I've seen is " [ELEMENTARY PARTICLE] yet to be confirmed".)