He’s familiar with a south part of London (3)
I believe the answer is:
ken
'he's' is the definition.
I cannot understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for ken that I've seen before include "Understanding - boy's name" , "Notice" , "Know; man's name" , "Awareness" , "Identify; -- Livingstone" .)