He's far away again (6)
I believe the answer is:
afresh
'again' is the definition.
(synonyms)
'he's far away' is the wordplay.
'away' indicates anagramming the letters (letters move away from their original places).
'hes'+'far'='hesfar'
'hesfar' is an anagram of 'AFRESH'.
(Other definitions for afresh that I've seen before include "Newly" , "In a different way" , "Academy award" , "In a new way" , "Anew, from the beginning" .)