He's far off once more (6)
I believe the answer is:
afresh
'once more' is the definition.
(I've seen this in another clue)
'he's far off' is the wordplay.
'off' indicates anagramming the letters.
'hes'+'far'='hesfar'
'hesfar' anagrammed gives 'AFRESH'.
(Other definitions for afresh that I've seen before include "Academy award" , "Newly" , "In a different way" , "In a new way" , "Anew, from the beginning" .)