Hesitant nurse clumsily collecting a trace of urine (6)
I believe the answer is:
unsure
'hesitant' is the definition.
(I've seen this in another clue)
'nurse clumsily collecting a trace of urine' is the wordplay.
'clumsily' is an anagram indicator.
'collecting' means one lot of letters goes inside another.
'a trace of' says to take the initial letters.
The initial letter of 'urine' is 'u'.
'nurse' anagrammed gives 'unsre'.
'unsre' placed around 'u' is 'UNSURE'.
(Other definitions for unsure that I've seen before include "Hesitant" , "Diffident, uncertain" , "Not certain or decided" , "self-confidence" , "Not certain, doubtful" .)