High priest's wit (6)

I believe the answer is:

esprit

'wit' is the definition.
(esprit can mean being witty)

'high priest's' is the wordplay.
'high' indicates anagramming the letters (can mean drunk or on drugs and hence disordered).
'priest' with letters rearranged gives 'ESPRIT'.

(Other definitions for esprit that I've seen before include "Vivaciousness" , "Vivacious wit" , "Group morale is . . . . . . de corps" , "What good corps needs" , "Liveliness of mind or spirit" .)

I've seen this clue in The Guardian.

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