High spot, like going round Windy End (5)
I believe the answer is:
andes
'high spot' is the definition.
(mountain range, a region of high mountains)
'like going round windy end' is the wordplay.
'like' becomes 'as'.
'going round' means one lot of letters goes inside another (some letters go around others).
'windy' is an anagram indicator (windy suggests disruption).
'end' anagrammed gives 'nde'.
'as' enclosing 'nde' is 'ANDES'.
(Other definitions for andes that I've seen before include "Danes seen in mountains" , "South American mountain system" , "Peak District" , "Major mountain range" , "World's longest mountain range" .)