Highly original form of male sin (7)
I believe the answer is:
seminal
'highly original' is the definition.
(I've seen this before)
'form of male sin' is the wordplay.
'form of' is an anagram indicator (the letters need to be in another 'form').
'male'+'sin'='malesin'
'malesin' is an anagram of 'SEMINAL'.
(Other definitions for seminal that I've seen before include "Of seed, or giving rise to new developments" , "Majorly influential" , "Menials (anag) - creative" , "Highy important" , "Major" .)