HIJKLMNO (5)
I believe the answer is:
water
'hijklmno' is the definition.
(terrible pun, chemical symbol H2O like 'H to O')
This is all the clue.
(Other definitions for water that I've seen before include "What can produce solution" , "Aqua" , "non-alcoholic drink" , "What makes the Somme" , "Transparent liquid" .)