Hiram's nephew resettled in US location (3,9)
I believe the answer is:
new hampshire
'us location' is the definition.
(I know that New Hampshire is a U.S. state)
'hiram's nephew resettled' is the wordplay.
'resettled' is an anagram indicator (letters must be resettled in a new order).
'hirams'+'nephew'='hiramsnephew'
'hiramsnephew' anagrammed gives 'NEW HAMPSHIRE'.
'in' acts as a link.
(Other definitions for new hampshire that I've seen before include "Northeast US state" , "State of New England" , "A NE US state" , "Part of America" .)