His opposition comes from Mrs Witherspoon (4)
I believe the answer is:
hers
'his opposition' is the definition.
I know nothing about this answer so I cannot judge whether this works.
'from mrs witherspoon' is the wordplay.
'from' says the answer is hidden in the clue.
'HERS' can be found hidden inside 'mrs witherspoon'.
'comes' acts as a link.
Can you help me to learn more?
(Other definitions for hers that I've seen before include "Belonging to the female" , "The woman's" .)