Hit rock bottom as pride's wounded (7)
I believe the answer is:
despair
'hit rock bottom' is the definition.
(thesaurus)
'as pride's wounded' is the wordplay.
'wounded' is an anagram indicator.
'as'+'pride'='aspride'
'aspride' is an anagram of 'DESPAIR'.
(Other definitions for despair that I've seen before include "Total loss of hope" , "Misery" , "Lose heart" , "Despond" , "An unhappy state" .)